AMPK: a therapeutic target of heart failure-not only metabolism regulation

Xuan Li; Jia Liu; Qingguo Lu; Di Ren; Xiaodong Sun; Thomas Rousselle; Yi Tan; Ji Li

doi:10.1042/BSR20181767

AMPK: a therapeutic target of heart failure-not only metabolism regulation

Biosci Rep. 2019 Jan 3;39(1):BSR20181767. doi: 10.1042/BSR20181767. Print 2019 Jan 31.

Authors

Xuan Li¹, Jia Liu^{1

2}, Qingguo Lu^{1

3}, Di Ren¹, Xiaodong Sun^{1

4}, Thomas Rousselle¹, Yi Tan^{5

6}, Ji Li⁷

Affiliations

¹ Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A.
² Department of Geriatrics, The First Hospital of Jilin University, Changchun 130021, China.
³ Department of Endocrinology and Metabolism, West China Hospital of Sichuan University, 37 Guoxue Lane, Chengdu 610041, China.
⁴ Department of Endocrinology, Affiliated Hospital of Weifang Medical University, Weifang, China.
⁵ Pediatic Research Institute, Department of Pediatrics, University of Louisville, Louisville, KY, U.S.A.
⁶ Wendy L. Novak Diabetes Care Center, University of Louisville, Louisville, KY, U.S.A.
⁷ Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A. [email protected].

Abstract

Heart failure (HF) is a serious disease with high mortality. The incidence of this disease has continued to increase over the past decade. All cardiovascular diseases causing dysfunction of various physiological processes can result in HF. AMP-activated protein kinase (AMPK), an energy sensor, has pleiotropic cardioprotective effects and plays a critical role in the progression of HF. In this review, we highlight that AMPK can not only improve the energy supply in the failing heart by promoting ATP production, but can also regulate several important physiological processes to restore heart function. In addition, we discuss some aspects of some potential clinical drugs which have effects on AMPK activation and may have value in treating HF. More studies, especially clinical trials, should be done to evaluate manipulation of AMPK activation as a potential means of treating HF.

Keywords: AMPK; heart failure; substrate metabolism.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

AMP-Activated Protein Kinases / antagonists & inhibitors*
AMP-Activated Protein Kinases / genetics
AMP-Activated Protein Kinases / metabolism
Adenosine Triphosphate / biosynthesis
Animals
Autophagy / drug effects
Autophagy / genetics
Cardiotonic Agents / therapeutic use*
Cardiovascular Diseases / complications
Cardiovascular Diseases / drug therapy*
Cardiovascular Diseases / genetics
Cardiovascular Diseases / pathology
Energy Metabolism / drug effects*
Energy Metabolism / genetics
Gene Expression Regulation
Heart Failure / drug therapy*
Heart Failure / etiology
Heart Failure / genetics
Heart Failure / pathology
Humans
Mitochondria / drug effects
Mitochondria / enzymology
Mitochondria / pathology
Myocardium / enzymology
Myocardium / pathology
Myocytes, Cardiac / drug effects
Myocytes, Cardiac / enzymology
Myocytes, Cardiac / pathology
Protein Kinase Inhibitors / therapeutic use*

Substances

Cardiotonic Agents
Protein Kinase Inhibitors
Adenosine Triphosphate
AMP-Activated Protein Kinases

Abstract

Publication types

MeSH terms

Substances

Grants and funding