Effect of On-Demand Oral Pre-exposure Prophylaxis With Tenofovir/Emtricitabine on Herpes Simplex Virus-1/2 Incidence Among Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Trial

Marie-Laure Chaix; Isabelle Charreau; Claire Pintado; Constance Delaugerre; Nadia Mahjoub; Laurent Cotte; Catherine Capitant; François Raffi; Eric Cua; Gilles Pialoux; Cécile Tremblay; Laurence Meyer; Jean-Michel Molina; ANRS IPERGAY Study Group

doi:10.1093/ofid/ofy295

Effect of On-Demand Oral Pre-exposure Prophylaxis With Tenofovir/Emtricitabine on Herpes Simplex Virus-1/2 Incidence Among Men Who Have Sex With Men: A Substudy of the ANRS IPERGAY Trial

Open Forum Infect Dis. 2018 Nov 8;5(11):ofy295. doi: 10.1093/ofid/ofy295. eCollection 2018 Nov.

Authors

Marie-Laure Chaix^{1

2}, Isabelle Charreau³, Claire Pintado⁴, Constance Delaugerre^{1

2}, Nadia Mahjoub¹, Laurent Cotte⁵, Catherine Capitant³, François Raffi⁶, Eric Cua⁷, Gilles Pialoux⁸, Cécile Tremblay⁹, Laurence Meyer^{3

10}, Jean-Michel Molina^{2

4}; ANRS IPERGAY Study Group

Collaborators

ANRS IPERGAY Study Group:
C Pintado, B Loze, C Delaugerre, P Charbonneau, C Gatey, D Ponscarme, P Penot, L Niedbalski, R Veron, J Delgado, E Dalle, S Parlier, I Madelaine, J Fonsart, M Danet, N Mahjoub, N Mezreb, K Moudachirou, S Morel, G Conort, F Lorho, M Meunier, W Rozenbaum, J M Molina, J Chas, C Monfort, J Foucoin, B Boissavy, S Cousseau, S Huon, M Danet, A Djessima, V Berrebi, A Adda, S le Nagat, L Zarka, J Berdougo, G Pialoux, C Chidiac, N Mzoughi, F Clement, A Decouty, C Chapolard, M Godinot, C Adouard-Groslafeige, J Koffi, A Pansu, A Becker, S Pailhes, F Bonnet, F Jeanblanc, C Brochier, X Teruin, S Rouby, L Gilly, L Cotte, C Etienne, F Tolonin, S Breaud, V Péchenot, S Bagge, T Cepitelli, P M Roger, E Rosenthal, E Cua, A Cheret, P Cornavin, S Vandamme, J Lambec, N Dumon, O Leclanche, T Huleux, R Biekre, O Robineau, H Melliez, H Bazus, A Pasquet, C Bernaud, M Besnier, B Bonnet, N Hall, M Cavellec, H Hue, L Larmet, M Colas, R Choquet, F Raffi, C Beauvais, P Arlotto, C Fortin, A Talbot, A Chamberland, A McKenzie, M Blanchette, R Rousseau, K Montheuth, J Otis, D Thompson, M Morin, M Wainberg, C Tremblay, L Meyer, C Capitant, I Charreau, B Guillon, E Netzer, N Leturque, J Binesse, V Foubert, M Saouzanet, F Euphrasie, D Carette, J P Aboulker, B Spire, L Sagaon-Teyssier, M Suzan, L Fressard, B Demoulin, G Cattin, N Lorente, V Doré, L Marchand, S Le Mestre, A Mennecier, E Choucair, N Etien, A Diallo, S Gibowski, M-C Simon, J-F Delfraissy, J M Le Gall, S Morel, V Pechenot, S Bagge, A Djessima Taba, M Danet, K Moudachirou, B Dos Santos, J Lambec, S Rouby, X Teruin, N Dumon, V Coquelin, P Brunet, L Gilly, T Cepitelli, R Porion, D Rojas Castro, B Spire, Jean-Michel Molina, Mark Wainberg, Benoit Trottier, Cécile Tremblay, Jean-Guy Baril, Gilles Pialoux, Laurent Cotte, Antoine Chéret, Armelle Pasquet, Eric Cua, Michel Besnier, Willy Rozenbaum, Christian Chidiac, Constance Delaugerre, Nathalie Bajos, Julie Timsit, Gilles Peytavin, Julien Fonsart, Isabelle Durand-Zaleski, Laurence Meyer, Jean-Pierre Aboulker, Bruno Spire, Marie Suzan-Monti, Gabriel Girard, Daniela Rojas Castro, Marie Préau, Michel Morin, David Thompson, Catherine Capitant, Lucie Marchand, Véronique Doré, Marie-Christine Simon, Isabelle Charreau, Joanne Otis, France Lert, Alpha Diallo, Séverine Gibowski, Cecile Rabian

Affiliations

¹ Virologie, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris, France.
² Institut National de la Santé et de la Recherche Médicale (INSERM) Unité, Centre National de la Recherche Scientifique Unité Mixte de Recherche, Institut Universitaire d'Hématologie, Sorbonne Paris Cité, Université Paris Diderot, Hôpital Saint Louis, France.
³ INSERM Service Commun, Villejuif, France.
⁴ Maladies Infectieuses, Hôpital Saint-Louis, Assistance Publique Hôpitaux de Paris, France.
⁵ Maladies Infectieuses, Hôpital de la Croix Rousse, Centre Hospitalier et Universitaire de Lyon, France.
⁶ Department of Infectious Diseases, University Hospital of Nantes and Centre d'Investigation Clinique, INSERM, Nantes.
⁷ Maladies Infectieuses, Hôpital de l'Archet, Centre Hospitalier de Nice, France.
⁸ Maladies Infectieuses, Hôpital Tenon, Assistance Publique Hôpitaux de Paris, France.
⁹ Maladies Infectieuses, Centre Hospitalier de l'Université de Montréal, Canada.
¹⁰ Université Paris-Sud, Université Paris-Saclay, France.

Abstract

We evaluated the impact of on-demand oral tenofovir disoproxil fumarate (TDF)/emtricitabine (FTC) for pre-exposure prophylaxis (PrEP) on herpes simplex virus (HSV)-1/2 incidence among men who have sex with men (MSM) enrolled in the ANRS IPERGAY trial. Serum samples were tested at baseline and at the last visit for HSV-1/2 antibodies. Overall HSV-1 incidence was 11.7 per 100 person-years; 16.2 and 7.8 per 100 person-years in the TDF/FTC and placebo arm, respectively (P = .19). Overall HSV-2 incidence was 7.6 per 100 person-years; 8.1 and 7.0 per 100 person-years in the TDF/FTC and placebo arm, respectively (P = .75). On-demand oral PrEP with TDF/FTC failed to reduce HSV-1/2 incidence in this population.

Keywords: HSV1/2 incidence; HSV1/2 prevalence; MSM; PrEP; TDF/FTC.