Abstract
Two trichothecene sesquiterpenoids, trichothecrotocins A (1) and B (2), and a merosesquiterpenoid racemate, (±)-trichothecrotocin C (3), were obtained from potato endophytic fungus Trichothecium crotocinigenum by bioguided isolation. Their structures were elucidated by extensive spectroscopic methods, electronic circular dichroism calculations, and single-crystal X-ray diffraction. Compounds 1 and 2 are trichothecenes possessing new ring systems. Compound 3 possesses a novel 6/6-5/5/5 fused ring system. Compounds 1-3 showed antiphytopathogenic activities with MIC values of 8-128 μg/mL.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alternaria / drug effects
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology*
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Ascomycota / chemistry*
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Dose-Response Relationship, Drug
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Fungicides, Industrial / chemistry
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Fungicides, Industrial / isolation & purification
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Fungicides, Industrial / pharmacology*
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Fusarium / drug effects
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Microbial Sensitivity Tests
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Molecular Conformation
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Phytophthora infestans / drug effects
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Rhizoctonia / drug effects
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Structure-Activity Relationship
Substances
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Antifungal Agents
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Fungicides, Industrial