Abstract
Macroscopic properties of physical and biological processes like friction, wetting, and adhesion or cell migration are controlled by interfacial properties at the nanoscopic scale. In an attempt to bridge simultaneously investigations at different scales, we demonstrate here how optical microscopy in Wet-Surface Ellipsometric Enhanced Contrast (Wet-SEEC) mode offers imaging and measurement of thin films at solid/liquid interfaces in the range 1-500 nm with lateral optical resolution. A live, label-free and noninvasive methodology integrated with microfluidic devices allowed here characterization of polymers and proteins patterns together with corresponding phenotypes of living cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Friction
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Microscopy / methods*
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Polymers
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Surface Properties
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Tomography, X-Ray Computed / methods*
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Wettability
Grants and funding
This work was supported by the Nanolane company (Le Mans), Solvay company (Bordeaux), Alveole company (Paris), C-Nano PACA Network, Labex INFORM network, Centuri network, ANR Recrute grant, the European Union’s Horizon 2020 research and innovation program under the Marie Skłodowska-Curie grant agreement No713750. It has also been carried out with the financial support of the Regional Council of Provence- Alpes-Côte d’Azur and of the A*MIDEX (n° ANR- 11-IDEX-0001- 02), funded by the Investissements d’Avenir project funded by the French Government, managed by the French National Research Agency (ANR). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. MM was employed by Nanolane. Nanolane provided support in the form of salaries for author MM, but did not have any additional role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of this author is articulated in the ‘author contributions’ section.