Quantitative measurement of urinary proteins in 2018: advantages, disadvantages, limits

Ann Biol Clin (Paris). 2018 Dec 1;76(6):627-631. doi: 10.1684/abc.2018.1389.

Abstract

Today, there is no reference method for the measurement of urinary proteins. The difficulties are that urine is a very complex biological fluid, and that there are a high intra-and inter-individual variability in the protein excretion rate. Progress has been made during the last thirty years, but high analytical variability persists among the colorimetric or turbidimetric methods used for urinary proteins measurement.

Keywords: measurement methods; urinary protein.

MeSH terms

  • Biological Variation, Individual
  • Biuret / chemistry
  • Costs and Cost Analysis
  • Evaluation Studies as Topic
  • Humans
  • Nephelometry and Turbidimetry / economics
  • Nephelometry and Turbidimetry / methods
  • Nephelometry and Turbidimetry / standards
  • Proteinuria / diagnosis*
  • Proteinuria / economics
  • Proteinuria / urine
  • Pyrogallol / chemistry
  • Reference Values
  • Rosaniline Dyes / chemistry
  • Urinalysis* / economics
  • Urinalysis* / methods
  • Urinalysis* / standards
  • Urinalysis* / trends
  • Urine Specimen Collection / standards

Substances

  • Rosaniline Dyes
  • Pyrogallol
  • Coomassie blue
  • Biuret