Radiation-induced vascular malformations in the brain, mimicking tumor in MRI-based treatment response assessment maps (TRAMs)

David Guez; David Last; Dianne Daniels; Shirley Sharabi; Dvora Nass; Ouzi Nissim; Roberto Spiegelmann; Galia Tzarfaty; Chen Hoffmann; Alisa Talianski; Yigal Shoshan; Yakov Fellig; Sagi Harnof; Zvi R Cohen; Leor Zach; Yael Mardor

doi:10.1016/j.ctro.2018.11.004

Radiation-induced vascular malformations in the brain, mimicking tumor in MRI-based treatment response assessment maps (TRAMs)

Clin Transl Radiat Oncol. 2018 Nov 14:15:1-6. doi: 10.1016/j.ctro.2018.11.004. eCollection 2019 Feb.

Authors

David Guez¹, David Last¹, Dianne Daniels¹, Shirley Sharabi¹, Dvora Nass^{2

3}, Ouzi Nissim⁴, Roberto Spiegelmann^{4

3}, Galia Tzarfaty^{5

3}, Chen Hoffmann^{5

3}, Alisa Talianski^{6

3}, Yigal Shoshan⁷, Yakov Fellig⁸, Sagi Harnof^{9

3}, Zvi R Cohen^{4

3}, Leor Zach^{6

3}, Yael Mardor^{1

3}

Affiliations

¹ Advanced Technology Center, Sheba Medical Center, Ramat-Gan 52621, Israel.
² Pathology Institute, Sheba Medical Center, Ramat-Gan 52621, Israel.
³ Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv 69978, Israel.
⁴ Neurosurgery Dept, Sheba Medical Center, Ramat-Gan 52621, Israel.
⁵ Radiology Institute, Sheba Medical Center, Ramat-Gan 52621, Israel.
⁶ Oncology Institute, Sheba Medical Center, Ramat-Gan 52621, Israel.
⁷ Neurosurgery Dept., Hadassah Medical Center, Jerusalem 91120, Israel.
⁸ Pathology Inst., Hadassah Medical Center, Jerusalem 91120, Israel.
⁹ Neurosurgery Dept., Rabin Medical Center, Petach Tikva 49100, Israel.

Abstract

•Of 310 brain tumors patients recruited, histology of 99 lesions was available.•Of those, 5 were histologically confirmed as radiation-induced malformations.•TRAMs cannot differentiate active tumor from vascular malformation.

Keywords: Brain tumors; MRI; RICM; RIT; Radiation; TRAMs; Vascular malformations.

Publication types

Case Reports