In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae

Evelyn E Nash; Tara C Henning; Cau D Pham; Kevin Pettus; Samera Sharpe; Ellen N Kersh

doi:10.1016/j.diagmicrobio.2018.10.021

In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae

Diagn Microbiol Infect Dis. 2019 Apr;93(4):369-371. doi: 10.1016/j.diagmicrobio.2018.10.021. Epub 2018 Nov 10.

Authors

Evelyn E Nash¹, Tara C Henning², Cau D Pham², Kevin Pettus², Samera Sharpe², Ellen N Kersh²

Affiliations

¹ Division of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA. Electronic address: [email protected].
² Division of Sexually Transmitted Disease Prevention, Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Atlanta, GA, USA.

Abstract

Neisseria gonorrhoeae quickly develops drug resistance. Time-kill curves revealed that EDTA and TOL-463 inhibit growth similar to penicillin, ciprofloxacin, and azithromycin. Furthermore, synergistic and additive antimicrobial interactions occurred when EDTA and TOL-463 were combined with penicillin or azithromycin, respectively, suggesting that further investigations into these unconventional antimicrobials may be advantageous.

Keywords: Antimicrobial resistance; Boric acid; Broth microdilution; EDTA; Neisseria gonorrhoeae.

MeSH terms

Anti-Bacterial Agents / pharmacology*
Boric Acids / pharmacology*
Drug Synergism
Edetic Acid / pharmacology*
Microbial Sensitivity Tests
Neisseria gonorrhoeae / drug effects*
Neisseria gonorrhoeae / growth & development

Substances

Anti-Bacterial Agents
Boric Acids
Edetic Acid
boric acid

Grants and funding

CC999999/Intramural CDC HHS/United States