Natural products are one of the most important sources of leading compounds in drug discovery. Until now, rapid screening and identification of biologically active components from natural products remain a technical challenge. Bio-affinity chromatography (BAC) based approaches hold great promise in screening potential bioactive ligands from complex samples. In this review, we summarized recent development of BAC in natural products screening, with a particular emphasis on the reported bio-affinity stationary phases and chromatographic supports as well as the applications of BAC coupled with GC-MS or LC-MS.
Keywords: Bio-affinity chromatography; Bioactive compounds screening; Natural products.
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