Data on the generation of rabbit infections and RPR titre changes in serum samples from syphilis patients at follow-up

Wen Liu; Xiaohong Zhang; Tie Zhao; Chenglong Zhou; Junxia Duan; Feijun Zhao

doi:10.1016/j.dib.2018.10.075

Data on the generation of rabbit infections and RPR titre changes in serum samples from syphilis patients at follow-up

Data Brief. 2018 Nov 7:21:2237-2241. doi: 10.1016/j.dib.2018.10.075. eCollection 2018 Dec.

Authors

Wen Liu¹, Xiaohong Zhang^{1

2}, Tie Zhao¹, Chenglong Zhou¹, Junxia Duan¹, Feijun Zhao¹

Affiliations

¹ Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, Pathogentic Biology Institute, University of South China, Hengyang 421001, China.
² Department of Histology and Embryology, Hengyang Medical College, University of South China, Hengyang 421001, China.

Abstract

The data presented in this article are related to the research article entitled "Performance of novel infection phase-dependent antigens in syphilis serodiagnosis and treatment efficacy determination". The rabbit model [1], [2] is an appropriate animal model for studying syphilis, a classic sexually transmitted disease (STD). Live Treponema pallidum (T. pallidum, Tp) and inactivated T. pallidum were inoculated in the backs of New Zealand rabbits. RT-PCR was performed to determine whether T. pallidum DNA could be detected in different groups. Sixty paired serum samples from patients at follow-up were tested by RPR and recombinant Tp0971-, Tp0768-, Tp0462- and Tp92-based ELISA.

Keywords: ELISA; RPR; Rabbit; Treponema pallidum.