Practical Ni-Catalyzed Cross-Coupling of Unsaturated Zinc Pivalates with Unsaturated Nonaflates and Triflates

Org Lett. 2019 Jan 4;21(1):36-39. doi: 10.1021/acs.orglett.8b03417. Epub 2018 Dec 18.

Abstract

A practical nickel-catalyzed cross-coupling of (hetero)aryl or alkynylzinc pivalates with various unsaturated nonaflates or triflates is described. Organozinc pivalates allow these cross-couplings to take place with high yields and a low catalyst loading (0.5 mol %). Couplings with ( E)- and ( Z)-alkenyl triflates proceed with retention of configuration.

Publication types

  • Research Support, Non-U.S. Gov't