Impaired Transplacental Transfer of Respiratory Syncytial Virus-neutralizing Antibodies in Human Immunodeficiency Virus-infected Versus -uninfected Pregnant Women

Sabelle Jallow; Yasmeen Agosti; Prudence Kgagudi; Megan Vandecar; Clare L Cutland; Eric A F Simões; Marta C Nunes; Melinda S Suchard; Shabir A Madhi

doi:10.1093/cid/ciy1071

Impaired Transplacental Transfer of Respiratory Syncytial Virus-neutralizing Antibodies in Human Immunodeficiency Virus-infected Versus -uninfected Pregnant Women

Clin Infect Dis. 2019 Jun 18;69(1):151-154. doi: 10.1093/cid/ciy1071.

Authors

Sabelle Jallow^{1

2

3}, Yasmeen Agosti^{1

2}, Prudence Kgagudi^{1

2}, Megan Vandecar³, Clare L Cutland^{1

2}, Eric A F Simões^{1

4}, Marta C Nunes^{1

2}, Melinda S Suchard³, Shabir A Madhi^{1

2}

Affiliations

¹ Medical Research Council, Respiratory and Meningeal Pathogens Research Unit, Johannesburg, South Africa.
² Department of Science and Technology/National Research Foundation, Vaccine Preventable Diseases Research, Faculty of Health Sciences, University of Witwatersrand, Johannesburg, South Africa.
³ Centre for Vaccines and Immunology, National Institute for Communicable Diseases of the National Health Laboratory Service, Johannesburg, South Africa.
⁴ University of Colorado School of Medicine, Colorado School of Public Health, Aurora.

PMID: 30561563
DOI: 10.1093/cid/ciy1071

Abstract

Human immunodeficiency virus (HIV)-exposed, uninfected infants have higher risks of respiratory syncytial virus-associated hospitalization than HIV-unexposed infants. Despite similar neutralizing antibody titers between HIV-infected and -uninfected women, maternal HIV infection and hypergammaglobulinemia were independently associated with lower titers in newborns. Maternal hypergammaglobulinemia was associated with lower cord-to-maternal antibody ratio.

Trial registration: ClinicalTrials.gov NCT02215226.

Keywords: RSV neutralizing antibody; human immunodeficiency virus; lower respiratory tract infection; maternal immunization; respiratory syncytial virus.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Antibodies, Neutralizing / physiology*
Antibodies, Viral / physiology*
Female
HIV Infections / complications*
Humans
Hypergammaglobulinemia
Immunity, Maternally-Acquired*
Infant, Newborn
Pregnancy
Respiratory Syncytial Virus, Human / immunology*

Substances

Antibodies, Neutralizing
Antibodies, Viral

Associated data

ClinicalTrials.gov/NCT02215226