Potassium chloride mixture may maintain hypokalaemia and hypertension

BMJ Case Rep. 2018 Dec 14;11(1):e223732. doi: 10.1136/bcr-2017-223732.

Abstract

Hypokalaemia can be treated with potassium chloride mixture. Some mixtures contain liquorice extract (glycyrrhizin) as a supplement to improve taste. Glycyrrhizin can cause pseudohyperaldosteronism and thereby result in hypertension and hypokalaemia. We here present a case where treatment with potassium chloride mixture causes hypertension and hypokalaemia in a 50-year-old woman. After unravelling differential diagnosis, the potassium chloride mixture was stopped. After the discontinuation, the patient's blood pressure was well managed and the potassium levels normalised.

Keywords: cardiovascular system; contraindications and precautions; endocrine system; fluid electrolyte and acid-base disturbances; hypertension.

Publication types

  • Case Reports

MeSH terms

  • Diagnosis, Differential
  • Female
  • Glycyrrhiza / adverse effects*
  • Glycyrrhizic Acid / adverse effects*
  • Glycyrrhizic Acid / therapeutic use
  • Humans
  • Hyperaldosteronism / blood
  • Hyperaldosteronism / chemically induced*
  • Hyperaldosteronism / diagnosis
  • Hypertension / blood
  • Hypertension / diagnosis
  • Hypertension / drug therapy*
  • Hypokalemia / blood
  • Hypokalemia / chemically induced*
  • Hypokalemia / diagnosis
  • Hypokalemia / etiology
  • Middle Aged
  • Potassium / blood
  • Potassium Chloride / adverse effects*
  • Potassium Chloride / pharmacology
  • Potassium Chloride / therapeutic use
  • Treatment Outcome
  • Verapamil / therapeutic use*

Substances

  • Potassium Chloride
  • Glycyrrhizic Acid
  • Verapamil
  • Potassium