Pain Wars: A New Hope

Kyle E Parker; Michael R Bruchas

doi:10.1016/j.neuron.2018.11.045

Pain Wars: A New Hope

Neuron. 2018 Dec 19;100(6):1280-1282. doi: 10.1016/j.neuron.2018.11.045.

Authors

Kyle E Parker¹, Michael R Bruchas²

Affiliations

¹ Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO, USA.
² Department of Anesthesiology, Division of Basic Research, Washington University School of Medicine, St. Louis, MO, USA; Center for the Neurobiology of Addiction, Pain, and Emotion, Departments of Anesthesiology and Pain Medicine, Department of Pharmacology, University of Washington, Seattle, WA, USA. Electronic address: [email protected].

PMID: 30571940
DOI: 10.1016/j.neuron.2018.11.045

Abstract

Nociceptin opioid peptide receptor agonists interact with mu-opioid receptor agonists for pain relief. A new study by Ding et al. (2018) examines a bifunctional nociceptin- and mu-opioid receptor agonist, AT-121, that provides analgesia without physiological side effects or abuse liability, offering a promising new hope toward better analgesics.

Publication types

Review

MeSH terms

Analgesics / therapeutic use*
Analgesics, Opioid / therapeutic use*
Animals
Humans
Nociceptin
Opioid Peptides / agonists
Opioid Peptides / metabolism
Pain / drug therapy*
Receptors, Opioid, mu / metabolism

Substances

Analgesics
Analgesics, Opioid
Opioid Peptides
Receptors, Opioid, mu