Pegylated Bovine Carboxyhemoglobin (SANGUINATE) in a Jehovah's Witness Undergoing Liver Transplant: A Case Report

M L Holzner; S DeMaria; B Haydel; N Smith; D Flaherty; S Florman

doi:10.1016/j.transproceed.2018.09.006

Pegylated Bovine Carboxyhemoglobin (SANGUINATE) in a Jehovah's Witness Undergoing Liver Transplant: A Case Report

Transplant Proc. 2018 Dec;50(10):4012-4014. doi: 10.1016/j.transproceed.2018.09.006. Epub 2018 Sep 8.

Authors

M L Holzner¹, S DeMaria², B Haydel³, N Smith², D Flaherty², S Florman³

Affiliations

¹ Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: [email protected].
² Department of Anesthesiology, Icahn School of Medicine at Mount Sinai, New York, NY.
³ Recanati/Miller Transplantation Institute, Icahn School of Medicine at Mount Sinai, New York, NY.

PMID: 30577305
DOI: 10.1016/j.transproceed.2018.09.006

Abstract

Liver transplantation in practicing Jehovah's Witnesses is challenging because of their religious beliefs preventing them from accepting allogenic blood products. Pegylated bovine carboxyhemoglobin (SANGUINATE) is an oxygen transfer agent, currently under investigation for the treatment of sickle cell disease, which may play a role in these patients by maximizing perioperative oxygen delivery. We report a case involving the use of SANGUINATE in a Jehovah's Witness undergoing liver transplant.

Publication types

Case Reports

MeSH terms

Animals
Blood Substitutes / therapeutic use*
Carboxyhemoglobin / therapeutic use*
Cattle
Female
Humans
Jehovah's Witnesses*
Liver Transplantation / methods*
Middle Aged

Substances

Blood Substitutes
Carboxyhemoglobin