Patients' perceptions and patient-reported outcomes in progressive-fibrosing interstitial lung diseases

Eur Respir Rev. 2018 Dec 21;27(150):180075. doi: 10.1183/16000617.0075-2018. Print 2018 Dec 31.

Abstract

The effects of interstitial lung disease (ILD) create a significant burden on patients, unsettling almost every domain of their lives, disrupting their physical and emotional well-being and impairing their quality of life (QoL). Because many ILDs are incurable, and there are limited reliably-effective, life-prolonging treatment options available, the focus of many therapeutic interventions has been on improving or maintaining how patients with ILD feel and function, and by extension, their QoL. Such patient-centred outcomes are best assessed by patients themselves through tools that capture their perceptions, which inherently incorporate their values and judgements. These patient-reported outcome measures (PROs) can be used to assess an array of constructs affected by a disease or the interventions implemented to treat it. Here, we review the impact of ILD that may present with a progressive-fibrosing phenotype on patients' lives and examine how PROs have been used to measure that impact and the effectiveness of therapeutic interventions.

Publication types

  • Review

MeSH terms

  • Activities of Daily Living
  • Cost of Illness
  • Disease Progression
  • Health Knowledge, Attitudes, Practice*
  • Humans
  • Lung / physiopathology*
  • Lung Diseases, Interstitial / diagnosis
  • Lung Diseases, Interstitial / physiopathology
  • Lung Diseases, Interstitial / psychology
  • Lung Diseases, Interstitial / therapy*
  • Patient Reported Outcome Measures*
  • Patients / psychology*
  • Phenotype
  • Pulmonary Fibrosis / diagnosis
  • Pulmonary Fibrosis / physiopathology
  • Pulmonary Fibrosis / psychology
  • Pulmonary Fibrosis / therapy*
  • Quality of Life
  • Recovery of Function
  • Severity of Illness Index
  • Time Factors
  • Treatment Outcome