Double-Stranded RNA Sensing Determines Epithelial Cell Identity

Chung-Ping Liao; Edem Tchegnon; Lu Q Le

doi:10.1016/j.jid.2018.08.008

Double-Stranded RNA Sensing Determines Epithelial Cell Identity

J Invest Dermatol. 2019 Jan;139(1):17-19. doi: 10.1016/j.jid.2018.08.008.

Authors

Chung-Ping Liao¹, Edem Tchegnon², Lu Q Le³

Affiliations

¹ Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
² Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Integrative Molecular and Biomedical Sciences Program, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
³ Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Integrative Molecular and Biomedical Sciences Program, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Hamon Center for Regenerative Science and Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas, USA. Electronic address: [email protected].

PMID: 30579424
DOI: 10.1016/j.jid.2018.08.008

Abstract

Skin epithelium is constituted by heterogeneous keratinocytes in different body areas. In this issue, Zhou et al. used transcriptome analysis to investigate the site-specific epidermal cell identity on volar skin. Keratin 9 is highly enriched in volar keratinocytes, and its expression is dependent on low expression of the double-stranded RNA receptor DDX58, suggesting that double-stranded RNA sensing could allow a potential approach to modulate skin thickness and durability.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Comment

MeSH terms

Epidermal Cells
Epithelial Cells
Keratinocytes*
RNA, Double-Stranded*
Skin

Substances

RNA, Double-Stranded