Abstract
BK virus is a polyoma virus which remains in latent phase in the urinary tract, particularly in the renal tubular epithelial cells. In immunosuppressed patients, it is activated and manifests as tubule-interstitial nephritis causing renal allograft dysfunction. A total of 402 patients who underwent renal allograft biopsy from 2013 to 2016 were included in this study; six patients were diagnosed to have BK virus nephropathy. Histopathology showed ground glass intra-nuclear inclusions accompanied by acute tubular injury, interstitial inflammation, and varying degree of interstitial fibrosis and tubular atrophy. Patients were managed with reduction in the overall immunosuppression. Only one patient progressed to graft failure on follow-up. The overall prevalence of polyoma virus at our center is 1.49%.
MeSH terms
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Adult
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Aged
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Allografts
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BK Virus / immunology
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BK Virus / pathogenicity*
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Female
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Graft Survival
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Humans
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Immunocompromised Host
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Immunosuppressive Agents / adverse effects
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India / epidemiology
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Kidney Diseases / diagnosis
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Kidney Diseases / epidemiology
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Kidney Diseases / immunology
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Kidney Diseases / virology*
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Kidney Transplantation / adverse effects*
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Kidney Transplantation / methods
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Living Donors*
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Male
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Middle Aged
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Opportunistic Infections / diagnosis
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Opportunistic Infections / epidemiology
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Opportunistic Infections / immunology
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Opportunistic Infections / virology*
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Polyomavirus Infections / diagnosis
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Polyomavirus Infections / epidemiology
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Polyomavirus Infections / immunology
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Polyomavirus Infections / virology*
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Prevalence
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Risk Factors
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Time Factors
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Treatment Outcome
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Tumor Virus Infections / diagnosis
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Tumor Virus Infections / epidemiology
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Tumor Virus Infections / immunology
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Tumor Virus Infections / virology*