Discovery of Half-life of Circulating Hepatitis B Surface Antigen in Patients With Chronic Hepatitis B Infection Using Heavy Water Labeling

Clin Infect Dis. 2019 Jul 18;69(3):542-545. doi: 10.1093/cid/ciy1100.

Abstract

In a pilot study, heavy water labeling was used to determine hepatitis B surface antigen (HBsAg) turnover rates in chronic hepatitis B (CHB) patients. The mean (standard deviation) half-life of HBsAg in blood was 6.7 (5.5) days, which reflects recent production in the liver and supports strategies aimed at reducing HBsAg production in CHB patients.

Keywords: HBV; deuterated water; half-life; hepatitis B surface antigen.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Adult
  • Aged
  • DNA, Viral / blood
  • Deuterium Oxide / administration & dosage*
  • Female
  • Half-Life
  • Hepatitis B Surface Antigens / blood*
  • Hepatitis B e Antigens / blood
  • Hepatitis B, Chronic / blood*
  • Hepatitis B, Chronic / virology*
  • Humans
  • Liver / virology
  • Male
  • Middle Aged
  • Pilot Projects
  • Saliva / virology

Substances

  • DNA, Viral
  • Hepatitis B Surface Antigens
  • Hepatitis B e Antigens
  • Deuterium Oxide