Facile synthesis of copper sulfide decorated reduced graphene oxide nanocomposite for high sensitive detection of toxic antibiotic in milk

Mani Govindasamy; Sea-Fue Wang; Sakthivel Kumaravel; R Jothi Ramalingam; Hamad A Al-Lohedan

doi:10.1016/j.ultsonch.2018.12.015

Facile synthesis of copper sulfide decorated reduced graphene oxide nanocomposite for high sensitive detection of toxic antibiotic in milk

Ultrason Sonochem. 2019 Apr:52:382-390. doi: 10.1016/j.ultsonch.2018.12.015. Epub 2018 Dec 10.

Authors

Mani Govindasamy¹, Sea-Fue Wang², Sakthivel Kumaravel³, R Jothi Ramalingam⁴, Hamad A Al-Lohedan⁵

Affiliations

¹ Department of Materials and Mineral Resources Engineering, National Taipei University of Technology, No. 1, Sec. 3, Chung-Hsiao East Rd., Taipei 106, Taiwan.
² Department of Materials and Mineral Resources Engineering, National Taipei University of Technology, No. 1, Sec. 3, Chung-Hsiao East Rd., Taipei 106, Taiwan. Electronic address: [email protected].
³ Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No.1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan.
⁴ Surfactant Research Chair, Chemistry Department, College of Science, King Saud University, P.O. Box-2455, Riyadh 11451, Saudi Arabia. Electronic address: [email protected].
⁵ Surfactant Research Chair, Chemistry Department, College of Science, King Saud University, P.O. Box-2455, Riyadh 11451, Saudi Arabia.

PMID: 30594521
DOI: 10.1016/j.ultsonch.2018.12.015

Abstract

The development of an effective technique for detecting antibiotic drugs remains a serious task due to their toxicity to public health. For this purpose, herein, we report an electrochemical detection based on Cu₂S nanosphere decorated reduced graphene oxide (RGO@Cu₂S NC) nanocomposite. A sonochemical-assisted method was adopted to prepare the nanocomposite. Subsequently, its morphological, elemental, and crystal structural aspects were analysed. The electrochemical properties were examined in order to ensure the material's suitability in electrocatalytic sensing. RGO@Cu₂S NC affixed screen-printed electrode was found to exhibit tremendous electrocatalytic capability toward chloramphenicol (CAP) reduction. A sensitive and reproducible amperometric CAP sensor was fabricated which was able to detect concentration at the nanomolar level. The method worked well even in real samples (fresh milk samples) and the results are evaluated by HPLC method and amperometric methods.

Keywords: Electrochemical approach; Food analysis; Modified electrode; Nanocomposite; Sensor; Sonochemical synthesis.

MeSH terms

Animals
Anti-Bacterial Agents / analysis*
Anti-Bacterial Agents / toxicity
Chemistry Techniques, Synthetic
Copper / chemistry*
Electrochemistry
Food Analysis / methods*
Food Contamination / analysis
Graphite / chemistry*
Hydrogen-Ion Concentration
Limit of Detection
Milk / chemistry*
Nanocomposites / chemistry*
Oxides / chemistry*
Sulfides / chemistry*

Substances

Anti-Bacterial Agents
Oxides
Sulfides
cuprous sulfide
Graphite
Copper