Case: This report describes 2 cases of failed decellularized "off-the-shelf" Chondrofix (Zimmer Biomet) osteochondral allografts within a year after implantation in a 44-year-old man and a 50-year-old woman.
Conclusion: Although it is a successful technique for cartilage repair, the use of osteochondral allograft transplantation has been limited by the availability of fresh grafts; therefore, decellularized osteochondral allografts recently have been developed. Physicians should be cautious when considering the use of these implants for the repair of articular cartilage lesions.