Competition for Food Drives Stem Cell Fate in Facultative Niches

Maëlle Givelet; Clémentine Lapoujade; Pierre Fouchet

doi:10.1016/j.stem.2018.12.010

Competition for Food Drives Stem Cell Fate in Facultative Niches

Cell Stem Cell. 2019 Jan 3;24(1):1-2. doi: 10.1016/j.stem.2018.12.010.

Authors

Maëlle Givelet¹, Clémentine Lapoujade², Pierre Fouchet³

Affiliations

¹ Institut Cochin, Inserm U1016, Paris 75014, France; Université Paris Descartes, Sorbonne Paris Cité, 22 rue Méchain, Paris, France; CEA DRF IBFJ IRCM, Laboratoire des Cellules Souches Germinales, 92265 Fontenay-aux-Roses, France; Université Paris Diderot, Sorbonne Paris Cité, INSERM, UMR 967, 92265 Fontenay-aux-Roses, France; Université Paris Sud, INSERM, UMR 967, 92265 Fontenay-aux-Roses, France.
² CEA DRF IBFJ IRCM, Laboratoire des Cellules Souches Germinales, 92265 Fontenay-aux-Roses, France; Université Paris Diderot, Sorbonne Paris Cité, INSERM, UMR 967, 92265 Fontenay-aux-Roses, France; Université Paris Sud, INSERM, UMR 967, 92265 Fontenay-aux-Roses, France.
³ CEA DRF IBFJ IRCM, Laboratoire des Cellules Souches Germinales, 92265 Fontenay-aux-Roses, France; Université Paris Diderot, Sorbonne Paris Cité, INSERM, UMR 967, 92265 Fontenay-aux-Roses, France; Université Paris Sud, INSERM, UMR 967, 92265 Fontenay-aux-Roses, France. Electronic address: [email protected].

PMID: 30609395
DOI: 10.1016/j.stem.2018.12.010

Abstract

Mechanisms regulating maintenance of the stem cell pool in facultative niches of the mammalian testis are poorly understood. In this issue of Cell Stem Cell, Kitadate et al. (2019) propose a minimal model in which stem cells compete for limited resources of fibroblast growth factors, which predicts their density during homeostasis and regenerative conditions.

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MeSH terms

Animals
Cell Differentiation
Germ Cells
Homeostasis
Male
Mitogens*
Stem Cells*

Substances

Mitogens