Integrating Genomics into Healthcare: A Global Responsibility

Zornitza Stark; Lena Dolman; Teri A Manolio; Brad Ozenberger; Sue L Hill; Mark J Caulfied; Yves Levy; David Glazer; Julia Wilson; Mark Lawler; Tiffany Boughtwood; Jeffrey Braithwaite; Peter Goodhand; Ewan Birney; Kathryn N North

doi:10.1016/j.ajhg.2018.11.014

Integrating Genomics into Healthcare: A Global Responsibility

Am J Hum Genet. 2019 Jan 3;104(1):13-20. doi: 10.1016/j.ajhg.2018.11.014.

Authors

Zornitza Stark¹, Lena Dolman², Teri A Manolio³, Brad Ozenberger⁴, Sue L Hill⁵, Mark J Caulfied⁶, Yves Levy⁷, David Glazer⁸, Julia Wilson⁹, Mark Lawler¹⁰, Tiffany Boughtwood¹¹, Jeffrey Braithwaite¹², Peter Goodhand², Ewan Birney¹³, Kathryn N North¹⁴

Affiliations

¹ Australian Genomics Health Alliance, Melbourne VIC 3052, Australia; Murdoch Children's Research Institute, Melbourne VIC 3052, Australia; Department of Paediatrics, University of Melbourne, Melbourne VIC 3052, Australia.
² Global Alliance for Genomics and Health, 661 University Avenue, Suite 510, Toronto, ON M5G 0A3, Canada; Ontario Institute for Cancer Research, 661 University Avenue, Suite 510, Toronto, ON M5G 0A3, Canada.
³ National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892-2152, USA.
⁴ All of Us Research Program, National Institutes of Health, Bethesda, MD 20892-2152, USA.
⁵ National Health Service England, Skipton House, 80 London Road, London SE1 6LH, UK.
⁶ Genomics England, Queen Mary University of London, Dawson Hall, London EC1M 6BQ, UK.
⁷ INSERM (French National Institute for Health and Medical Research), 75654 Paris Cedex 13, France.
⁸ Verily Life Sciences, 269 East Grand Avenue, South San Francisco, CA 94080, USA.
⁹ Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
¹⁰ Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Road, Belfast BT9 7AE, UK.
¹¹ Australian Genomics Health Alliance, Melbourne VIC 3052, Australia; Murdoch Children's Research Institute, Melbourne VIC 3052, Australia.
¹² Australian Genomics Health Alliance, Melbourne VIC 3052, Australia; Australian Institute of Health Innovation, Macquarie University, 75 Talavera Road, Sydney, NSW 2113, Australia.
¹³ Global Alliance for Genomics and Health, 661 University Avenue, Suite 510, Toronto, ON M5G 0A3, Canada; European Molecular Biology Laboratory-European Bioinformatics Institute, Hinxton, Cambridge CB10 1SD, UK.
¹⁴ Australian Genomics Health Alliance, Melbourne VIC 3052, Australia; Murdoch Children's Research Institute, Melbourne VIC 3052, Australia; Department of Paediatrics, University of Melbourne, Melbourne VIC 3052, Australia; Global Alliance for Genomics and Health, 661 University Avenue, Suite 510, Toronto, ON M5G 0A3, Canada. Electronic address: [email protected].

Abstract

Genomic sequencing is rapidly transitioning into clinical practice, and implementation into healthcare systems has been supported by substantial government investment, totaling over US$4 billion, in at least 14 countries. These national genomic-medicine initiatives are driving transformative change under real-life conditions while simultaneously addressing barriers to implementation and gathering evidence for wider adoption. We review the diversity of approaches and current progress made by national genomic-medicine initiatives in the UK, France, Australia, and US and provide a roadmap for sharing strategies, standards, and data internationally to accelerate implementation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Australia
Delivery of Health Care / economics
Delivery of Health Care / methods*
Delivery of Health Care / organization & administration*
Delivery of Health Care / trends
Evidence-Based Medicine
France
Genetics, Medical / economics
Genetics, Medical / methods*
Genetics, Medical / organization & administration*
Genetics, Medical / trends
Genomics / economics
Genomics / trends*
Humans
Information Dissemination
International Cooperation*
Private Sector
United Kingdom
United States

Abstract

Publication types

MeSH terms

Grants and funding