Abstract
Cancer remains a serious healthcare problem despite significant improvements in early detection and treatment approaches in the past few decades. Novel biomarkers for diagnosis and therapeutic strategies are urgently needed. In recent years, long noncoding RNAs (lncRNAs) have been reported to be aberrantly expressed in tumors and show crosstalk with key cancer-related signaling pathways. In this review, we summarized the current progress of research on cytoplasmic lncRNAs and their roles in regulating cancer signaling and tumor progression, further characterization of which may lead to effective approaches for cancer prevention and therapy.
Keywords:
Long noncoding RNA (lncRNA); Cancer signaling; Cancer therapy; Biomarker.
MeSH terms
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Animals
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Biomarkers, Tumor / genetics
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Biomarkers, Tumor / metabolism
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Cytoplasm / genetics
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Cytoplasm / metabolism
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Hippo Signaling Pathway
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Humans
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Hypoxia-Inducible Factor 1, alpha Subunit / genetics
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Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
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Neoplasms / genetics*
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Neoplasms / metabolism
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Phosphatidylinositol 3-Kinases / genetics
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Phosphatidylinositol 3-Kinases / metabolism
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Protein Serine-Threonine Kinases / genetics
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Protein Serine-Threonine Kinases / metabolism
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Proto-Oncogene Proteins c-akt / genetics
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Proto-Oncogene Proteins c-akt / metabolism
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RNA, Long Noncoding / genetics*
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RNA, Long Noncoding / metabolism
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Signal Transduction / genetics
Substances
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Biomarkers, Tumor
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HIF1A protein, human
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Hypoxia-Inducible Factor 1, alpha Subunit
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RNA, Long Noncoding
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Protein Serine-Threonine Kinases
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Proto-Oncogene Proteins c-akt