Abstract
Two patients are described with severe coagulation disturbances, in one instance leading to extensive skin bleeding, secondary to the use of cefamandole. This cefalosporin antibiotic carries the same N-methylthiotetrazole side chain as moxalactam. Pathogenetic mechanisms leading to hypoprothrombinemia, its prevention and treatment are discussed.
MeSH terms
-
Aged
-
Amputation, Surgical
-
Cefamandole / adverse effects*
-
Cefamandole / therapeutic use
-
Diabetic Angiopathies / surgery
-
Female
-
Hemorrhagic Disorders / chemically induced*
-
Humans
-
Hypoprothrombinemias / chemically induced*
-
Kidney Transplantation
-
Male
-
Middle Aged
-
Pneumonia / drug therapy
-
Postoperative Complications / drug therapy