AllergoOncology: Microbiota in allergy and cancer-A European Academy for Allergy and Clinical Immunology position paper

Eva Untersmayr; Heather J Bax; Christoph Bergmann; Rodolfo Bianchini; Wendy Cozen; Hannah J Gould; Karin Hartmann; Debra H Josephs; Francesca Levi-Schaffer; Manuel L Penichet; Liam O'Mahony; Aurelie Poli; Frank A Redegeld; Franziska Roth-Walter; Michelle C Turner; Luca Vangelista; Sophia N Karagiannis; Erika Jensen-Jarolim

doi:10.1111/all.13718

AllergoOncology: Microbiota in allergy and cancer-A European Academy for Allergy and Clinical Immunology position paper

Allergy. 2019 Jun;74(6):1037-1051. doi: 10.1111/all.13718. Epub 2019 Mar 6.

Authors

Eva Untersmayr¹, Heather J Bax^{2

3}, Christoph Bergmann⁴, Rodolfo Bianchini⁵, Wendy Cozen^{6

7

8}, Hannah J Gould^{9

10}, Karin Hartmann¹¹, Debra H Josephs^{2

3}, Francesca Levi-Schaffer¹², Manuel L Penichet^{13

14

15

16

17}, Liam O'Mahony¹⁸, Aurelie Poli¹⁹, Frank A Redegeld²⁰, Franziska Roth-Walter⁵, Michelle C Turner^{21

22

23

24}, Luca Vangelista²⁵, Sophia N Karagiannis², Erika Jensen-Jarolim^{1

5}

Affiliations

¹ Institute of Pathophysiology and Allergy Research, Center of Pathophysiology, Infectiology and Immunology, Medical University Vienna, Vienna, Austria.
² St. John's Institute of Dermatology, School of Basic & Medical Biosciences, King's College London, Guy's Hospital, London, UK.
³ School of Cancer and Pharmaceutical Sciences, King's College London, Guy's Hospital, London, UK.
⁴ ENT Research Institute for Clinical Studies, Essen, Germany.
⁵ Comparative Medicine, The Interuniversity Messerli Research Institute, University of Veterinary Medicine Vienna, Medical University Vienna, University Vienna, Vienna, Austria.
⁶ Center for Genetic Epidemiology, Department of Preventive Medicine, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
⁷ Department of Pathology, Keck School of Medicine of University of Southern California, Los Angeles, California, USA.
⁸ Norris Comprehensive Cancer Center, Keck School of Medicine of Los Angeles, Los Angeles, California, USA.
⁹ Randall Centre for Cell and Molecular Biophysics, School of Basic & Medical Biosciences, King's College London, New Hunt's House, London, UK.
¹⁰ Medical Research Council & Asthma UK Centre in Allergic Mechanisms of Asthma, London, UK.
¹¹ Department of Dermatology, University of Luebeck, Luebeck, Germany.
¹² Pharmacology and Experimental Therapeutics Unit, School of Pharmacy, Faculty of Medicine, The Institute for Drug Research, The Hebrew University of Jerusalem, Jerusalem, Israel.
¹³ Division of Surgical Oncology, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
¹⁴ Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, California, USA.
¹⁵ Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California, USA.
¹⁶ The Molecular Biology Institute, University of California, Los Angeles, California, USA.
¹⁷ UCLA AIDS Institute, Los Angeles, California, USA.
¹⁸ Departments of Medicine and Microbiology, APC Microbiome Ireland, National University of Ireland, Cork, Ireland.
¹⁹ Department of Infection and Immunity, Luxembourg Institute of Health, Esch-sur-Alzette, Luxembourg.
²⁰ Division of Pharmacology, Faculty of Science, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands.
²¹ Barcelona Institute for Global Health (ISGlobal), Barcelona, Spain.
²² Universitat Pompeu Fabra (UPF), Barcelona, Spain.
²³ CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
²⁴ McLaughlin Centre for Population Health Risk Assessment, University of Ottawa, Ottawa, Ontario, Canada.
²⁵ Department of Biomedical Sciences, Nazarbayev University School of Medicine, Astana, Kazakhstan.

Abstract

The microbiota can play important roles in the development of human immunity and the establishment of immune homeostasis. Lifestyle factors including diet, hygiene, and exposure to viruses or bacteria, and medical interventions with antibiotics or anti-ulcer medications, regulate phylogenetic variability and the quality of cross talk between innate and adaptive immune cells via mucosal and skin epithelia. More recently, microbiota and their composition have been linked to protective effects for health. Imbalance, however, has been linked to immune-related diseases such as allergy and cancer, characterized by impaired, or exaggerated immune tolerance, respectively. In this AllergoOncology position paper, we focus on the increasing evidence defining the microbiota composition as a key determinant of immunity and immune tolerance, linked to the risk for the development of allergic and malignant diseases. We discuss novel insights into the role of microbiota in disease and patient responses to treatments in cancer and in allergy. These may highlight opportunities to improve patient outcomes with medical interventions supported through a restored microbiome.

Keywords: allergy; cancer; hygiene hypothesis; microbiota; oncoimmunology.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Animals
Asthma / immunology*
Asthma / metabolism
Asthma / microbiology*
Bacteria / genetics
Bacteria / metabolism*
Child
Child, Preschool
Diet
Epithelium / immunology
Epithelium / microbiology
Female
Gastrointestinal Microbiome / immunology*
Host Microbial Interactions / immunology*
Humans
Hygiene Hypothesis
Immunity, Cellular
Infant
Male
Micronutrients
Mucous Membrane / immunology
Mucous Membrane / microbiology
Neoplasms / immunology*
Neoplasms / metabolism
Neoplasms / microbiology*
Phylogeny

Substances

Micronutrients

Abstract

Publication types

MeSH terms

Substances

Grants and funding