Moxifloxacin in Chronic Obstructive Pulmonary Disease: Pharmacokinetics and Penetration into Bronchial Secretions in Ward and Intensive Care Unit Patients

Antimicrob Agents Chemother. 2019 Feb 26;63(3):e01974-18. doi: 10.1128/AAC.01974-18. Print 2019 Mar.

Abstract

This study aimed to evaluate the pharmacokinetic profile of moxifloxacin (MXF) in serum and sputum/bronchial secretions of 22 patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD) hospitalized in the ward and intensive care unit (ICU). The data showed that ICU patients had lower concentrations in secretions (P = 0.01). However, no other statistically significant differences were observed in pharmacokinetic parameters and penetration in secretions between ward and ICU patients. MXF showed a favorable pharmacokinetic profile, and the pharmacodynamic targets for common pathogens for AECOPD were achieved.

Keywords: COPD; ICU; bronchial secretions; moxifloxacin; pharmacokinetics.

MeSH terms

  • Aged
  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Infections / prevention & control*
  • Critical Care
  • Disease Progression
  • Female
  • Humans
  • Intensive Care Units
  • Male
  • Microbial Sensitivity Tests
  • Moxifloxacin / pharmacokinetics*
  • Moxifloxacin / therapeutic use
  • Prospective Studies
  • Pulmonary Disease, Chronic Obstructive / microbiology*

Substances

  • Anti-Bacterial Agents
  • Moxifloxacin