Summary: Simulating realistic clonal dynamics of tumors is an important topic in cancer genomics. Here, we present Phylogeny guided Simulator for Tumor Evolution, a tool that can simulate different types of tumor samples including single sector, multi-sector bulk tumor as well as single-cell tumor data under a wide range of evolutionary trajectories. Phylogeny guided Simulator for Tumor Evolution provides an efficient tool for understanding clonal evolution of cancer.
Availability and implementation: PSiTE is implemented in Python and is available at https://github.com/hchyang/PSiTE.
Supplementary information: Supplementary data are available at Bioinformatics online.
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