Catalytic Formal Benzylic C-H Bond Functionalization of 2,5-Dialkylfuran Derivatives with Ferrocenyl Alcohols as Alkylation Reagents

Org Lett. 2019 Feb 1;21(3):627-631. doi: 10.1021/acs.orglett.8b03701. Epub 2019 Jan 17.

Abstract

The inert benzylic C-H bond of π-electron-rich heteroaromatic 2,5-dialkylfuran derivatives was conveniently functionalized with ferrocenyl alcohols as alkylation reagents under catalytic acidic conditions at room temperature, which features chemo- and regiospecificity, mild and metallic catalyst-free conditions, and environmental benignity.

Publication types

  • Research Support, Non-U.S. Gov't