Stimuli-Responsive Luminescent Copper Nanoclusters in Alginate and Their Sensing Ability for Glucose

ACS Appl Mater Interfaces. 2019 Feb 13;11(6):6561-6567. doi: 10.1021/acsami.8b20835. Epub 2019 Jan 31.

Abstract

Visually observable pH-responsive luminescent materials are developed by integrating the properties of aggregation-induced emission enhancement of Cu nanoclusters (NCs) and the Ca2+-triggered gelatin of alginate. Sodium alginate, CaCO3 nanoparticles, and Cu NCs are dispersed in aqueous solution, which is in a transparent fluid state, showing weak photoluminescence (PL). The introduced H+ can react with the CaCO3 nanoparticles to produce free Ca2+, which can cross-link the alginate chains into gel networks. Meanwhile, a dramatic increase in the PL intensity of Cu NCs and a blue shift in the PL peak appeared, assigned to the Ca2+-induced enhancement and gelatin-induced enhancement, respectively. Their potential application as a sensor for glucose is also demonstrated based on the principle that glucose oxidase can recognize glucose and produce H+, which further triggers the above-mentioned two-stage enhancement. A linear relationship between the PL intensity and the concentration of glucose in the range of 0.1-2.0 mM is obtained, with the limit of detection calculated as 3.2 × 10-5 M.

Keywords: aggregation-induced emission; alginate; glucose; metal nanoclusters; photoluminescence; stimuli-responsive materials.

MeSH terms

  • Alginates / chemistry*
  • Amino Acids / chemistry
  • Copper / chemistry*
  • Dopamine / chemistry
  • Gels / chemistry
  • Glucose / analysis*
  • Glucose / metabolism
  • Glucose Oxidase / metabolism
  • Hydrogen-Ion Concentration
  • Luminescent Measurements / methods*
  • Metal Nanoparticles / chemistry*

Substances

  • Alginates
  • Amino Acids
  • Gels
  • Copper
  • Glucose Oxidase
  • Glucose
  • Dopamine