Advances in Understanding Ischemic Stroke Physiology and the Impact of Vasculopathy in Children With Sickle Cell Disease

Stroke. 2019 Feb;50(2):266-273. doi: 10.1161/STROKEAHA.118.020482.

Authors

Kristin P Guilliams^{1

2}, Melanie E Fields², Michael M Dowling³

Affiliations

¹ From the Department of Neurology (K.P.G.), Washington University School of Medicine, St Louis, MO.
² Department of Pediatrics (K.P.G., M.E.F.), Washington University School of Medicine, St Louis, MO.
³ Department of Pediatrics and Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas (M.M.D.).

No abstract available

Keywords: anemia; cerebrovascular circulation; hemolysis; hydroxyurea; oxygen consumption; stroke.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

MeSH terms

Acute Disease
Anemia, Sickle Cell / complications*
Anemia, Sickle Cell / physiopathology
Anemia, Sickle Cell / therapy
Blood Transfusion
Brain Ischemia / diagnostic imaging
Brain Ischemia / etiology*
Brain Ischemia / physiopathology
Cerebral Arteries / pathology
Cerebrovascular Circulation
Child
Contraindications, Drug
Humans
Hydroxyurea / adverse effects
Hydroxyurea / therapeutic use
Hypoxia, Brain / etiology
Magnetic Resonance Imaging
Moyamoya Disease / complications
Moyamoya Disease / physiopathology
Neuroimaging
Oxygen / blood
Stroke / etiology
Stroke / prevention & control
Ultrasonography, Doppler, Transcranial

Substances

Oxygen
Hydroxyurea

Grants and funding