Bioactive cytosporone derivatives isolated from the mangrove-derived fungus Dothiorella sp. ML002

Cai-Juan Zheng; Guo-Lei Huang; Hai-Xia Liao; Rong-Qing Mei; You-Ping Luo; Guang-Ying Chen; Qing-Ying Zhang

doi:10.1016/j.bioorg.2019.01.015

Bioactive cytosporone derivatives isolated from the mangrove-derived fungus Dothiorella sp. ML002

Bioorg Chem. 2019 Apr:85:382-385. doi: 10.1016/j.bioorg.2019.01.015. Epub 2019 Jan 12.

Authors

Cai-Juan Zheng¹, Guo-Lei Huang², Hai-Xia Liao³, Rong-Qing Mei¹, You-Ping Luo², Guang-Ying Chen¹, Qing-Ying Zhang⁴

Affiliations

¹ State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, People's Republic of China; Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, People's Republic of China; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, People's Republic of China.
² Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158, People's Republic of China; Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, People's Republic of China.
³ Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, People's Republic of China; College of Chemistry and Food Sciences, Yulin Normal University, Yulin 537000, People's Republic of China.
⁴ State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, People's Republic of China. Electronic address: [email protected].

PMID: 30665032
DOI: 10.1016/j.bioorg.2019.01.015

Abstract

Three new cytosporone derivatives dothiorelones K-M (1, 2 and 7), together with six known ones (3-6, 8 and 9) were isolated from the mangrove-derived fungus Dothiorella sp. ML002. Their structures were determined by comprehensive 1D, 2D NMR spectroscopic and HR-ESI-MS spectroscopic data. Compounds 1, 2 and 5 displayed inhibitory activities against α-glucosidase with the IC₅₀ values of 22.0, 77.9 and 5.4 μg/mL, respectively. Additionally, compounds 1, 2, and 5 also exhibited antibacterial activities against Staphylococcus aureus (ATCC 6538) with the same MIC values of 50 μg/mL, respectively. The results indicated that cytosporone derivatives will be useful to as diabetes control agents.

Keywords: Cytosporone derivatives; Dothiorella sp.; α-glucosidase activity.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / isolation & purification
Anti-Bacterial Agents / pharmacology
Anti-Bacterial Agents / toxicity
Ascomycota / chemistry*
Benzopyrans / isolation & purification
Benzopyrans / pharmacology*
Benzopyrans / toxicity
Cell Line, Tumor
Glycoside Hydrolase Inhibitors / isolation & purification
Glycoside Hydrolase Inhibitors / pharmacology
Glycoside Hydrolase Inhibitors / toxicity
Humans
Microbial Sensitivity Tests
Resorcinols / isolation & purification
Resorcinols / pharmacology*
Resorcinols / toxicity
Staphylococcus aureus / drug effects

Substances

Anti-Bacterial Agents
Benzopyrans
Glycoside Hydrolase Inhibitors
Resorcinols