Approaches to understanding and interpreting the risks of red blood cell transfusion in neonates

A K Keir; H New; N Robitaille; G L Crighton; E M Wood; S J Stanworth

doi:10.1111/tme.12575

Approaches to understanding and interpreting the risks of red blood cell transfusion in neonates

Transfus Med. 2019 Aug;29(4):231-238. doi: 10.1111/tme.12575. Epub 2019 Jan 21.

Authors

A K Keir^{1

2}, H New^{3

4}, N Robitaille⁵, G L Crighton^{6

7}, E M Wood⁷, S J Stanworth^{8

9}

Affiliations

¹ Healthy Mothers, Babies and Children, The South Australian Medical and Research Institute, North Adelaide, South Australia, Australia.
² Robinson Research Institute and the Adelaide Medical School, The University of Adelaide, Adelaide, South Australia, Australia.
³ NHS Blood and Transplant, London, UK.
⁴ Imperial College London, London, UK.
⁵ Division of Hematology-Oncology, Department of Pediatrics, CHU Sainte-Justine, Montréal, Quebec, Canada.
⁶ Department of Haematology, Royal Children's Hospital, Melbourne, Victoria, Australia.
⁷ Transfusion Research Unit, Department of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
⁸ NHS Blood and Transplant and Department of Haematology, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.
⁹ Radcliffe Department of Medicine, University of Oxford, Oxford, UK.

PMID: 30666733
DOI: 10.1111/tme.12575

Abstract

In this review, we explore how to assess potential harm related to neonatal transfusion practice. We consider different sources of information, including passive or active surveillance systems such as registries, observational studies, randomised trials and systematic reviews. Future research directions are discussed.

Keywords: adverse effects; haemovigilance; infants.

Publication types

Systematic Review

MeSH terms

Erythrocyte Transfusion*
Humans
Infant, Newborn
Randomized Controlled Trials as Topic
Registries*
Risk Factors
Transfusion Reaction / prevention & control*