Gene-function studies in systemic lupus erythematosus

Curr Opin Rheumatol. 2019 Mar;31(2):185-192. doi: 10.1097/BOR.0000000000000572.

Abstract

Purpose of review: The aim of this review is to discuss recent developments in our understanding of how systemic lupus erythematosus (SLE)-associated genes contribute to autoimmunity.

Recent findings: Gene-function studies have revealed mechanisms through which SLE-associated alleles of IFIH1, TNFAIP3, IRF5, and PRDM1 likely contribute to the development of autoimmunity. Novel research has identified Mac-1 (encoded by ITGAM), CaMK4, and iRhom2 as plausible therapeutic targets in lupus nephritis.

Summary: The work discussed in this review has broad implications for our understanding of the pathogenesis of SLE and for the development of novel therapeutic strategies.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • CD11b Antigen / biosynthesis
  • CD11b Antigen / genetics*
  • Gene Expression Regulation*
  • Genetic Predisposition to Disease*
  • Genetic Therapy / methods*
  • Humans
  • Lupus Erythematosus, Systemic / genetics*
  • Lupus Erythematosus, Systemic / metabolism
  • Lupus Erythematosus, Systemic / therapy
  • RNA / genetics*

Substances

  • CD11b Antigen
  • ITGAM protein, human
  • RNA