Yes-associated protein expression in paired primary and local recurrent breast cancer and its clinical significance

Nianhua Ding; Ting Huang; Jiaqi Yuan; Jie Mao; Yumei Duan; Weihua Liao; Zhi Xiao

doi:10.1016/j.currproblcancer.2018.12.005

Yes-associated protein expression in paired primary and local recurrent breast cancer and its clinical significance

Curr Probl Cancer. 2019 Oct;43(5):429-437. doi: 10.1016/j.currproblcancer.2018.12.005. Epub 2019 Jan 17.

Authors

Nianhua Ding¹, Ting Huang², Jiaqi Yuan², Jie Mao², Yumei Duan³, Weihua Liao⁴, Zhi Xiao⁵

Affiliations

¹ Radiology Department, Xiangya Hospital, Central South University, Changsha, China; Center for Molecular Medicine, Xiangya Hospital, Central South University, Changsha, China.
² Department of Breast Surgery, Xiangya Hospital, Central South University, Changsha, China.
³ Department of Pathology, Xiangya Hospital, Central South University, Changsha, China.
⁴ Radiology Department, Xiangya Hospital, Central South University, Changsha, China.
⁵ Department of Breast Surgery, Xiangya Hospital, Central South University, Changsha, China; Clinical Research Center For Breast Cancer Control and Prevention In Human Province, Changsha, China. Electronic address: [email protected].

PMID: 30678988
DOI: 10.1016/j.currproblcancer.2018.12.005

Abstract

Yes-associated protein (YAP) protein acts as tumorigenic factor in many solid tumors, but the situation in breast cancer is under debate. Here, we would analyze its status in breast cancer. YAP expression in the 110 primary breast cancer and their paired local recurrent tumors was investigated. Clinicopathologic data for age, histologic grading, hormone status, lymph nodes and HER2 status were also gathered and analyzed. 46.4% (51/110) primary breast cancer tissues were positive for total YAP expression which was significantly higher than that in the recurrent tissues (10.9%; P < 0.05). The expression of total YAP protein in the primary breast cancer tissues was positively associated with the tumor size, especially in triple negative breast cancer (TNBC) subtype (P < 0.05). Higher total or nuclear YAP expression in the primary tumor was correlated with poor disease-free survival among patients with TNBC (P < 0.05). In the multivariate models, nuclear YAP expression was an independently prognostic factor in TNBC. High total or nuclear YAP expression predicts poor prognosis among patients with TNBC. It might be a therapeutic target for TNBC in the future.

Keywords: Clinical significance; Paired breast cancer tissues; Triple-negative breast cancer; Yes-associated protein.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adaptor Proteins, Signal Transducing / analysis
Adaptor Proteins, Signal Transducing / metabolism*
Adult
Aged
Breast / pathology*
Carcinoma, Ductal, Breast / mortality*
Carcinoma, Ductal, Breast / pathology
Carcinoma, Ductal, Breast / therapy
Disease-Free Survival
Female
Follow-Up Studies
Humans
Lymph Nodes / pathology
Lymphatic Metastasis / pathology*
Middle Aged
Neoplasm Recurrence, Local / mortality*
Neoplasm Recurrence, Local / pathology
Prognosis
Receptor, ErbB-2 / analysis
Receptor, ErbB-2 / metabolism
Receptors, Estrogen / analysis
Receptors, Estrogen / metabolism
Receptors, Progesterone / analysis
Receptors, Progesterone / metabolism
Transcription Factors / analysis
Transcription Factors / metabolism*
Triple Negative Breast Neoplasms / mortality*
Triple Negative Breast Neoplasms / pathology
Triple Negative Breast Neoplasms / therapy
YAP-Signaling Proteins

Substances

Adaptor Proteins, Signal Transducing
Receptors, Estrogen
Receptors, Progesterone
Transcription Factors
YAP-Signaling Proteins
YAP1 protein, human
ERBB2 protein, human
Receptor, ErbB-2