Knowledge, attitude, and practice regarding infection and vaccination in patients with rheumatic diseases in China

Hum Vaccin Immunother. 2019;15(5):1100-1105. doi: 10.1080/21645515.2019.1568160. Epub 2019 Mar 19.

Abstract

Objective Vaccines including pneumococcal and influenza vaccines are recommended in patients with immunosuppressive treatment. However, vaccine coverage remains extremely low. Our study was to investigate vaccination uptake, knowledge, attitude and practice (KAP) towards certain vaccinations among these patients, and to identify the factors influencing willingness to be vaccinated. Methods A cross-sectional survey was conducted among patients with rheumatic diseases in a tertiary hospital in China. Baseline assessments were completed by using questionnaires including vaccination uptake and KAP towards certain infections and vaccinations. Results 235 patients completed the study. Mean age was 39.69 years old, while 66.4% were females. Only 6.4% of the participants once had taken vaccine in recent five years. One patient had influenza vaccination, and none ever took pneumococcal vaccine. 3.8% had doctor's recommendation on taking influenza, pneumococcal or herpes zoster vaccine. Major reasons given for not being vaccinated included "unnecessary" (8.9%) and "troublesome to take vaccines" (8.5%). Patients would take influenza or pneumococcal vaccines if they had heard of them before, had knowledge of infection, and had belief in vaccine's safety and reliability (p < 0.05). Conclusion Vaccine coverage among people with rheumatic diseases was low in China. Methods to improve KAP toward infections and vaccinations should be taken.

Keywords: Vaccination; infection; influenza; pneumonia; rheumatic diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • China
  • Cross-Sectional Studies
  • Female
  • Health Knowledge, Attitudes, Practice*
  • Humans
  • Influenza Vaccines / administration & dosage
  • Influenza, Human / prevention & control
  • Male
  • Middle Aged
  • Patients / psychology*
  • Pneumococcal Infections / prevention & control
  • Pneumococcal Vaccines / administration & dosage
  • Reproducibility of Results
  • Rheumatic Diseases*
  • Surveys and Questionnaires
  • Vaccination / psychology*
  • Vaccination / statistics & numerical data
  • Vaccine Potency
  • Vaccines / administration & dosage*

Substances

  • Influenza Vaccines
  • Pneumococcal Vaccines
  • Vaccines

Grants and funding

This work was supported a health management platform of spondyloarthritis and hyperuricemia (A2968), and Distinguished Young Scholar Candidates Programme for The Third Affiliated Hospital of Sun Yat-Sen University and Pearl River Nova Program of Guangzhou (Grant No. 201610010005).