Spontaneous Bone Regeneration After Closure of the Hard Palate Cleft: A Literature Review

Purpose: A wide range of surgical techniques have been described for the treatment of palatal clefts. Some of these surgical procedures result in postoperative osteogenesis at the palatal fissure. The aims of this review were to discuss the current approaches to cleft palate surgery leading to spontaneous bone regeneration and to compare these different procedures. Moreover, the causes of bone regeneration, effects on maxillary growth, and factors affecting bone regeneration on the hard palate are discussed.

Materials and methods: The selected articles were found via MEDLINE and Web of Science. The keywords for the search were "cleft palate," "bone regeneration," "palatoplasty," "reconstructive surgical procedures," and "cleft palate surgery." Studies that examined the effect of primary palatoplasty on spontaneous bone regeneration in the hard palate in children were included in this review. Four articles were analyzed in the qualitative synthesis.

Results: Because of differences in patient characteristics and evaluation methods, it was difficult to compare different surgical procedures. The use of a mucoperiosteal flap in combination with adequate closure of the mucosa is needed to obtain bone formation. The area with the largest amount of regenerated bone was located in the middle of the hard palate. In the literature, it was found that complete closure was considered unfavorable because of the negative effects on maxillary growth, but more studies are needed to confirm this. Of the factors that have been studied, only age turned out to be borderline relevant.

Conclusions: Only a few studies with small sample sizes have been published on bone regeneration in the hard palate. More research is needed to validate these findings.