Investigating the causal relationship between neuroticism and depression via Mendelian randomization

D Speed; G Hemani; M S Speed; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; A D Børglum; S D Østergaard

doi:10.1111/acps.13009

Investigating the causal relationship between neuroticism and depression via Mendelian randomization

Acta Psychiatr Scand. 2019 Apr;139(4):395-397. doi: 10.1111/acps.13009. Epub 2019 Feb 17.

Authors

D Speed^{1

2

3}, G Hemani⁴, M S Speed^{3

5

6}; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium; A D Børglum^{7

8

9}, S D Østergaard^{1

5

6

8

9}

Affiliations

¹ Aarhus Institute for Advanced Studies, Aarhus University, Aarhus, Denmark.
² UCL Genetics Institute, University College London, London, UK.
³ Bioinformatics Research Centre (BiRC), Aarhus University, Aarhus, Denmark.
⁴ Medical Research Council (MRC) Integrative Epidemiology Unit, University of Bristol, Bristol, UK.
⁵ Department of Affective Disorders, Aarhus University Hospital, Aarhus, Denmark.
⁶ Department of Clinical Medicine, Aarhus University, Aarhus, Denmark.
⁷ Department of Biomedicine and Center for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark.
⁸ The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark.
⁹ Center for Genomics and Personalized Medicine, Aarhus, Denmark.

No abstract available

Publication types

Letter
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Depression / genetics*
Depressive Disorder, Major / genetics*
Genome-Wide Association Study / statistics & numerical data*
Humans
Mendelian Randomization Analysis*
Neuroticism*
Polymorphism, Single Nucleotide
Risk Factors

Publication types

MeSH terms

Grants and funding