Factors Associated With Meningioma Detected in a Population-Based Sample

Mayo Clin Proc. 2019 Feb;94(2):254-261. doi: 10.1016/j.mayocp.2018.07.026.

Abstract

Objective: To determine the frequency of incidental meningioma and identify associated factors in a population-based sample of participants who systematically underwent brain imaging.

Patients and methods: We searched the Mayo Clinic Study of Aging, a population-based sample of Olmsted County, Minnesota, residents who underwent longitudinal magnetic resonance imaging of the brain. Using a text search of radiologists' notes for 2402 individuals (median age, 75.0 years) who underwent imaging between August 10, 2005, and July 31, 2014, we identified 52 patients (2.2%) who had at least one meningioma. We estimated the association of selected risk factors with the presence of meningioma using odds ratios and 95% CIs from logistic regression models adjusted for age and sex. Based on these results, we moved the most significant variables forward to a multivariable model.

Results: Controlling for age and sex, significant associations with the presence of meningioma included higher body mass index (odds ratio [OR], 1.06; 95% CI, 1.01-1.12; P=.03), nonsteroidal anti-inflammatory drugs (OR, 2.11; 95% CI, 1.13-3.95; P=.02), aspirin (OR, 1.90; 95% CI, 1.05-3.46; P=.04), and blood pressure-lowering medication (OR, 2.06; 95% CI, 1.06-3.99; P=.03). Lower risk was associated with male sex (OR, 0.51; 95% CI, 0.29-0.90; P=.02), coronary artery disease (OR, 0.46; 95% CI, 0.22-0.97; P=.04), and higher self-reported anxiety (OR, 0.88; 95% CI, 0.78-0.98; P=.02). Simultaneous adjustment for all of these factors except aspirin in a multivariable model did not attenuate these associations (concordance, 0.71).

Conclusion: In a population-based sample of 2402 participants, 52 (2.2%) had an incidental meningioma. They were more likely to be female and have higher body mass index. Meningioma was also associated with certain medications (nonsteroidal anti-inflammatory drugs and blood pressure-lowering medications) and inversely with anxiety and coronary artery disease.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Body Mass Index
  • Brain / diagnostic imaging*
  • Coronary Artery Disease / complications
  • Female
  • Hormone Replacement Therapy / adverse effects
  • Humans
  • Incidence
  • Incidental Findings*
  • Magnetic Resonance Imaging / methods*
  • Male
  • Meningeal Neoplasms / diagnosis*
  • Meningeal Neoplasms / epidemiology
  • Meningeal Neoplasms / etiology
  • Meningioma / diagnosis*
  • Meningioma / epidemiology
  • Meningioma / etiology
  • Minnesota / epidemiology
  • Odds Ratio
  • Population Surveillance*
  • Retrospective Studies
  • Risk Assessment / methods*
  • Risk Factors

Substances

  • Anti-Inflammatory Agents, Non-Steroidal