Anticatabolic Effects of Ketone Bodies in Skeletal Muscle

Andrew P Koutnik; Dominic P D'Agostino; Brendan Egan

doi:10.1016/j.tem.2019.01.006

Anticatabolic Effects of Ketone Bodies in Skeletal Muscle

Trends Endocrinol Metab. 2019 Apr;30(4):227-229. doi: 10.1016/j.tem.2019.01.006. Epub 2019 Jan 31.

Authors

Andrew P Koutnik¹, Dominic P D'Agostino¹, Brendan Egan²

Affiliations

¹ Department of Molecular Pharmacology and Physiology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA.
² National Institute for Cellular Biotechnology, School of Health and Human Performance, Dublin City University, Glasnevin, Dublin 9, Ireland. Electronic address: [email protected].

PMID: 30712977
DOI: 10.1016/j.tem.2019.01.006

Abstract

The ketone bodies acetoacetate (AcAc) and β-hydroxybutyrate (βHB) are the subject of renewed interest given recently established pleiotropic effects regulating inflammation, oxidative stress, and gene expression. Anticatabolic effects of β-hydroxybutyrate have recently been demonstrated in human skeletal muscle under inflammatory insult, thereby expanding upon the wide-ranging therapeutic applications of nutritional ketosis.

Keywords: acetoacetate; atrophy; cachexia; inflammation; muscle protein breakdown; β-hydroxybutyrate.

Publication types

Review

MeSH terms

3-Hydroxybutyric Acid*
Acetoacetates*
Diet, Ketogenic*
Humans
Inflammation / metabolism*
Ketone Bodies*
Ketosis / metabolism*
Muscle, Skeletal / metabolism*

Substances

Acetoacetates
Ketone Bodies
acetoacetic acid
3-Hydroxybutyric Acid