Abstract
The present paper describes the morphological and functional alterations of the gastric mucosal microvascular endothelium under restraint-stressed condition. On the basis of the direct cholinergic innervation of capillaries and non-muscular venules in the gastric mucosa, these endothelial changes would be caused by the stress-induced overstimulation of the cholinergic nerves and modified by the degranulation of mast cells, contributing to the stress-induced ulcer formation as schematically illustrated in Fig. 10.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Aged
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Animals
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Endothelium, Vascular / pathology*
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Female
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Gastric Mucosa / blood supply*
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Gastric Mucosa / innervation
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Gastric Mucosa / pathology
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Hematoma, Subdural / complications
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Humans
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Hypothalamus / physiopathology
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Mast Cells / metabolism
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Mast Cells / pathology
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Microcirculation
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Peptic Ulcer Hemorrhage / etiology
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Rats
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Receptors, Cholinergic / analysis
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Restraint, Physical
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Stomach Ulcer / etiology*
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Stomach Ulcer / physiopathology
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Stress, Physiological / complications*
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Stress, Physiological / physiopathology
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Stress, Psychological / complications
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Stress, Psychological / physiopathology