Mixed-ligand complexes of platinum(II) as curing agents for pBR322 and pBR329 (ColE1) plasmids in Escherichia coli

V V Lakshmi; P Sridhar; B T Khan; H Polasa

doi:10.1099/00221287-134-7-1977

Mixed-ligand complexes of platinum(II) as curing agents for pBR322 and pBR329 (ColE1) plasmids in Escherichia coli

J Gen Microbiol. 1988 Jul;134(7):1977-81. doi: 10.1099/00221287-134-7-1977.

Authors

V V Lakshmi¹, P Sridhar, B T Khan, H Polasa

Affiliation

¹ I. Department of Microbiology, Osmania University, Andhra Pradesh, India.

PMID: 3073190
DOI: 10.1099/00221287-134-7-1977

Abstract

The mixed-ligand complexes of platinum(II) [Pt(Gly)(uracil)Cl2].H2O and [Pt(His)(adenine)]-Cl.2H2O eliminated multicopy plasmids with the ColE1 origin of replication in Escherichia coli with 100% frequency. However, plasmids of the IncF1, H1 and X groups were totally refractory to these agents under similar conditions.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Escherichia coli
Hydrogen-Ion Concentration
Ligands
Organoplatinum Compounds / pharmacology*
Plasmids / drug effects*

Substances

Ligands
Organoplatinum Compounds
histidinatoadenine platinum(II)
dichloroglycineuracil platinum(II)