Simulating Transplant Small-for-size Grafts Using Human Liver Monosegments: The Impact of Portal Perfusion Pressure

M Mohamed; L Kang; C Zhang; B Edenfield; J Sykes; T Brown; J L Johnson; F Rehman; J H Nguyen

doi:10.1016/j.transproceed.2018.12.028

Simulating Transplant Small-for-size Grafts Using Human Liver Monosegments: The Impact of Portal Perfusion Pressure

Transplant Proc. 2019 Apr;51(3):919-924. doi: 10.1016/j.transproceed.2018.12.028. Epub 2019 Jan 9.

Authors

M Mohamed¹, L Kang¹, C Zhang¹, B Edenfield², J Sykes¹, T Brown³, J L Johnson³, F Rehman⁴, J H Nguyen⁵

Affiliations

¹ Department of Transplantation, Mayo Clinic Florida, Jacksonville, Florida.
² Department of Cancer Biology, Mayo Clinic Florida, Jacksonville, Florida.
³ Cardiothoracic Surgery, Mayo Clinic Florida, Jacksonville, Florida.
⁴ Department of Biology, University of North Florida, Jacksonville, Florida.
⁵ Department of Transplantation, Mayo Clinic Florida, Jacksonville, Florida. Electronic address: [email protected].

Abstract

Small-for-size-liver grafts (SFSG) in adult transplant recipients have elevated risk of graft failure, limiting its application in clinical liver transplantation. Relevant preclinical model of SFSG is lacking. Relevant to deceased-donor split liver transplant and living-donor liver transplant in adult recipients, in this study, we present our initial characterization of SFSG model using monosegments of a discarded human donor liver.

MeSH terms

Adult
Graft Survival
Humans
Liver Circulation / physiology*
Liver Transplantation / methods*
Living Donors*
Perfusion / methods*
Portal Pressure / physiology*
Portal Vein / physiopathology*
Portal Vein / surgery
Time Factors
Transplants*
Treatment Outcome

Grants and funding

R21 AG052822/AG/NIA NIH HHS/United States