Postoperative radiation performed at the same surgical facility associated with improved overall survival in oral cavity squamous cell carcinoma

Head Neck. 2019 Jul;41(7):2299-2308. doi: 10.1002/hed.25697. Epub 2019 Feb 9.

Abstract

Background: The purpose of this analysis is to evaluate whether postoperative radiotherapy (PORT) at the same facility as surgery portends to better survival outcomes compared to PORT given at a different facility.

Methods: Patients underwent upfront surgery at the National Cancer Database reporting facility followed by PORT. PORT was coded as performed at either the same facility or at a different facility as surgery.

Results: A total of 10 832 patients were selected. Five-year overall survival (OS) was higher in patients undergoing PORT at the same facility: 52.5% vs 48.4% (P < 0.001). PORT performed at the same facility was associated with improved OS under multivariate (HR, 0.92; P = 0.01) and propensity score matched (hazard ratio, 0.90; P = 0.004) analyses.

Conclusions: OS was better among patients with head and neck cancer who received PORT at the same facility as surgery.

Keywords: National Cancer Database (NCDB); facility location; oral cavity cancer; outcomes; postoperative radiation therapy (PORT).

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Cancer Care Facilities / statistics & numerical data*
  • Carcinoma, Squamous Cell / mortality*
  • Carcinoma, Squamous Cell / therapy*
  • Chemotherapy, Adjuvant
  • Databases, Factual
  • Female
  • Humans
  • Male
  • Middle Aged
  • Mouth Neoplasms / mortality*
  • Mouth Neoplasms / therapy*
  • Multivariate Analysis
  • Radiotherapy, Adjuvant*
  • United States / epidemiology
  • Young Adult