Abstract
A novel near-infrared fluorescent light-up probe with a tumor-homing pentapeptide, CREKA (Cys-Arg-Glu-Lys-Ala), specifically binds to fibrin-fibronectin complexes was rationally designed and developed for biomedical imaging. Its superior practical applications in tumor imaging and drug-induced liver injury detection are well demonstrated for the first time.
MeSH terms
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A549 Cells
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Aniline Compounds / chemical synthesis
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Aniline Compounds / chemistry*
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Animals
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Benzopyrans / chemical synthesis
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Benzopyrans / chemistry*
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Carbon Tetrachloride
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Chemical and Drug Induced Liver Injury / diagnostic imaging*
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Female
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Fibrin / chemistry
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Fibronectins / chemistry
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Fluorescent Dyes / chemical synthesis
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Fluorescent Dyes / chemistry*
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Humans
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Mice, Inbred BALB C
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Microscopy, Fluorescence / methods
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Neoplasms / diagnostic imaging*
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Oligopeptides / chemistry
Substances
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Aniline Compounds
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Benzopyrans
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Fibronectins
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Fluorescent Dyes
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Oligopeptides
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cysteinyl-arginyl-glutamyl-lysyl-alanyl
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Fibrin
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Carbon Tetrachloride