Invasion by Force: The C. elegans Anchor Cell Leads the Way

Savvas Nikolaou; Laura M Machesky

doi:10.1016/j.devcel.2019.01.024

Invasion by Force: The C. elegans Anchor Cell Leads the Way

Dev Cell. 2019 Feb 11;48(3):287-288. doi: 10.1016/j.devcel.2019.01.024.

Authors

Savvas Nikolaou¹, Laura M Machesky²

Affiliations

¹ CRUK Beatson Institute and Institute of Cancer Sciences, University of Glasgow, G61 1BD, Glasgow, UK.
² CRUK Beatson Institute and Institute of Cancer Sciences, University of Glasgow, G61 1BD, Glasgow, UK. Electronic address: [email protected].

PMID: 30753832
DOI: 10.1016/j.devcel.2019.01.024

Abstract

How cells breach basement membrane barriers remains an area of active research. In this issue of Developmental Cell, Kelley et al. (2019) reveal that the C. elegans anchor cell uses physical force to breach basement membrane in the absence of matrix metalloproteases during its developmental invasion.

Publication types

Comment

MeSH terms

Actins
Adenosine Triphosphate
Animals
Basement Membrane
Caenorhabditis elegans Proteins*
Caenorhabditis elegans*
Matrix Metalloproteinases
Polymerization

Substances

Actins
Caenorhabditis elegans Proteins
Adenosine Triphosphate
Matrix Metalloproteinases

Grants and funding

24452/CRUK_/Cancer Research UK/United Kingdom