Young adult-onset, very slowly progressive cognitive decline with spastic paraparesis in Alzheimer's disease with cotton wool plaques due to a novel presenilin1 G417S mutation

Acta Neuropathol Commun. 2019 Feb 12;7(1):19. doi: 10.1186/s40478-019-0672-z.

Tomoko Miki^{1

2}, Osamu Yokota^{3

4}, Takashi Haraguchi⁵, Takeshi Ikeuchi⁶, Bin Zhu⁶, Shintaro Takenoshita¹, Seishi Terada¹, Norihito Yamada¹

¹ Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan.
² Department of Psychiatry, Kinoko Espoir Hospital, Okayama, Japan.
³ Department of Neuropsychiatry, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama, 700-8558, Japan. [email protected].
⁴ Department of Psychiatry, Kinoko Espoir Hospital, Okayama, Japan. [email protected].
⁵ Department of Neurology, National Hospital Organization Minami-Okayama Medical Center, Okayama, Japan.
⁶ Department of Molecular Neuroscience, Brain Research Institute, Niigata University, Niigata, Japan.

No abstract available

Keywords: Alzheimer’s disease; Cotton wool plaques; Disease duration; Presenilin 1 mutation; Spastic paraparesis.

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