Abstract
Saussurea involucrata, known for the abundant bioactive components, is a precious traditional Chinese medicine. In this study, a novel guaiane sesquiterpenoid glycoside named (1R, 5R, 6R, 7R, 8S, 11S)-11, 13-dihydrodehydrocostuslactone-8-O-6'-2''(E)-butenoyl-β-D-glucopyranoside (1), together with seven known compounds (2-8) were isolated from the dried aerial part of S. involucrata. Their structures were elucidated by spectroscopic and physico-chemical analyses. The antioxidant and anti-inflammatory activities of compound 1 were investigated. And compound 1 showed weak radical scavenging activity and low inhibitory activity on nitric oxide (NO) production.
Keywords:
Saussurea involucrata; anti-inflammatory; antioxidant; sesquiterpenoid glycoside.
MeSH terms
-
Anti-Inflammatory Agents / chemistry
-
Anti-Inflammatory Agents / isolation & purification
-
Anti-Inflammatory Agents / pharmacology
-
Antioxidants / chemistry
-
Antioxidants / isolation & purification
-
Antioxidants / pharmacology
-
Free Radical Scavengers / chemistry
-
Free Radical Scavengers / isolation & purification
-
Free Radical Scavengers / pharmacology
-
Glycosides / chemistry
-
Glycosides / isolation & purification*
-
Glycosides / pharmacology
-
Medicine, Chinese Traditional*
-
Nitric Oxide / antagonists & inhibitors
-
Plant Extracts / chemistry
-
Saussurea / chemistry*
-
Sesquiterpenes / chemistry
-
Sesquiterpenes / isolation & purification*
-
Sesquiterpenes / pharmacology
Substances
-
Anti-Inflammatory Agents
-
Antioxidants
-
Free Radical Scavengers
-
Glycosides
-
Plant Extracts
-
Sesquiterpenes
-
Nitric Oxide