Core Entrustable Professional Activities in Clinical Pharmacology for Entering Residency: Common Problem Drugs and How to Prescribe Them

J Clin Pharmacol. 2019 Jul;59(7):915-922. doi: 10.1002/jcph.1389. Epub 2019 Feb 15.

Abstract

Although the medical profession strives for safe prescribing, most medications are unique challenges even when prescribed by an experienced provider. In this article we discuss the pitfalls associated with drug interactions between commonly used antibiotics and anticoagulants, the complexities associated with the administration of novel reversible anticoagulants, the often-overlooked severe adverse drug reactions from commonly used classes of medications such as corticosteroids, the nuances of managing an acetaminophen overdose, and uncommon yet serious adverse events associated with the use of contraceptive hormone drugs.

Keywords: GME; UME; acetaminophen; contraception; entrustable professional activities (EPA) in clinical pharmacology; ethinyl estradiol; medical education; norethindrone; novel oral anticoagulants (NOAC); opioids; prescribing practices; problem drugs; psychosis; steroids; thrombosis; toxicity.

Publication types

  • Case Reports

MeSH terms

  • Acetaminophen / adverse effects*
  • Adolescent
  • Adrenal Cortex Hormones / adverse effects*
  • Aged
  • Anti-Bacterial Agents / adverse effects*
  • Anticoagulants / adverse effects*
  • Contraceptives, Oral, Hormonal / adverse effects*
  • Drug Interactions
  • Drug Overdose
  • Female
  • Humans
  • Internship and Residency
  • Male
  • Middle Aged
  • Young Adult

Substances

  • Adrenal Cortex Hormones
  • Anti-Bacterial Agents
  • Anticoagulants
  • Contraceptives, Oral, Hormonal
  • Acetaminophen