Clinical utility and prospective of TMS-EEG

Sara Tremblay; Nigel C Rogasch; Isabella Premoli; Daniel M Blumberger; Silvia Casarotto; Robert Chen; Vincenzo Di Lazzaro; Faranak Farzan; Fabio Ferrarelli; Paul B Fitzgerald; Jeanette Hui; Risto J Ilmoniemi; Vasilios K Kimiskidis; Dimitris Kugiumtzis; Pantelis Lioumis; Alvaro Pascual-Leone; Maria Concetta Pellicciari; Tarek Rajji; Gregor Thut; Reza Zomorrodi; Ulf Ziemann; Zafiris J Daskalakis

doi:10.1016/j.clinph.2019.01.001

Clinical utility and prospective of TMS-EEG

Clin Neurophysiol. 2019 May;130(5):802-844. doi: 10.1016/j.clinph.2019.01.001. Epub 2019 Jan 19.

Authors

Sara Tremblay¹, Nigel C Rogasch², Isabella Premoli³, Daniel M Blumberger⁴, Silvia Casarotto⁵, Robert Chen⁶, Vincenzo Di Lazzaro⁷, Faranak Farzan⁸, Fabio Ferrarelli⁹, Paul B Fitzgerald¹⁰, Jeanette Hui⁴, Risto J Ilmoniemi¹¹, Vasilios K Kimiskidis¹², Dimitris Kugiumtzis¹³, Pantelis Lioumis⁴, Alvaro Pascual-Leone¹⁴, Maria Concetta Pellicciari¹⁵, Tarek Rajji⁴, Gregor Thut¹⁶, Reza Zomorrodi⁴, Ulf Ziemann¹⁷, Zafiris J Daskalakis⁴

Affiliations

¹ Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, ON, Canada; Royal Ottawa Institute of Mental Health Research, Ottawa, ON, Canada. Electronic address: [email protected].
² Brain and Mental Health Research Hub, School of Psychological Sciences, Monash Institute of Cognitive and Clinical Neuroscience, and Monash Biomedical Imaging, Monash University, Australia.
³ Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience (IoPPN), King's College London, London, UK.
⁴ Temerty Centre for Therapeutic Brain Intervention, Centre for Addiction and Mental Health, and Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
⁵ Department of Biomedical and Clinical Sciences "L. Sacco", University of Milan, Milan, Italy.
⁶ Krembil Research Institute, University Health Network and Division of Neurology, Department of Medicine, University of Toronto, Canada.
⁷ Unit of Neurology, Neurophysiology, Neurobiology, Department of Medicine, Università Campus Bio-Medico di Roma, via Álvaro del Portillo 21, 00128 Rome, Italy.
⁸ Simon Fraser University, School of Mechatronic Systems Engineering, B.C., Canada.
⁹ Department of Psychiatry, University of Pittsburgh, PA, USA.
¹⁰ Epworth Healthcare, The Epworth Clinic, Camberwell, Victoria, Australia; Monash Alfred Psychiatry Research Centre, The Alfred and Monash University Central Clinical School, Victoria, Australia.
¹¹ Department of Neuroscience and Biomedical Engineering, Aalto University School of Science, Espoo, Finland.
¹² Laboratory of Clinical Neurophysiology, Medical School, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
¹³ Department of Electrical and Computer Engineering, Aristotle University of Thessaloniki, Thessaloniki 54124, Greece.
¹⁴ Berenson-Allen Center for Noninvasive Brain Stimulation and Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, MA 02215, USA.
¹⁵ Non-invasive Brain Stimulation Unit, Department of Behavioral and Clinical Neurology, Santa Lucia Foundation IRCCS, Rome, Italy.
¹⁶ Centre for Cognitive Neuroimaging, Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, UK.
¹⁷ Department of Neurology & Stroke, and Hertie Institute for Clinical Brain Research, University of Tübingen, Germany.

PMID: 30772238
DOI: 10.1016/j.clinph.2019.01.001

Abstract

Concurrent transcranial magnetic stimulation and electroencephalography (TMS-EEG) has emerged as a powerful tool to non-invasively probe brain circuits in humans, allowing for the assessment of several cortical properties such as excitability and connectivity. Over the past decade, this technique has been applied to various clinical populations, enabling the characterization and development of potential TMS-EEG predictors and markers of treatments and of the pathophysiology of brain disorders. The objective of this article is to present a comprehensive review of studies that have used TMS-EEG in clinical populations and to discuss potential clinical applications. To provide a technical and theoretical framework, we first give an overview of TMS-EEG methodology and discuss the current state of knowledge regarding the use of TMS-EEG to assess excitability, inhibition, plasticity and connectivity following neuromodulatory techniques in the healthy brain. We then review the insights afforded by TMS-EEG into the pathophysiology and predictors of treatment response in psychiatric and neurological conditions, before presenting recommendations for how to address some of the salient challenges faced in clinical TMS-EEG research. Finally, we conclude by presenting future directions in line with the tremendous potential of TMS-EEG as a clinical tool.

Keywords: Biomarker; Clinical populations; Electroencephalography (EEG); TMS–EEG; Transcranial magnetic stimulation (TMS); Treatment.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Brain / physiology*
Electroencephalography / methods*
Evoked Potentials / physiology*
Humans
Nerve Net / physiology*
Transcranial Magnetic Stimulation / methods*

Abstract

Publication types

MeSH terms

Grants and funding