Prostate Cancer Pulmonary Metastasis Presenting as a Ground-Glass Pulmonary Nodule on 68Ga-PSMA-11 PET/CT

Clin Nucl Med. 2019 May;44(5):e353-e356. doi: 10.1097/RLU.0000000000002499.

Abstract

Ga-prostate-specific membrane antigen 11 (PSMA) PET/CT imaging accurately depicts metastatic prostate adenocarcinoma (PCa). Pulmonary metastases of PCa are often overlooked on follow-up imaging in patients after initial treatment and following androgen deprivation therapy. Here we present a rare case of biopsy-proven PCa pulmonary metastasis with a ground-glass appearance. The increased PSMA expression and the evolving CT features of the solid component of the ground-glass nodule detected by PSMA PET/CT imaging led to surgical resection and PET/CT-guided therapy.

Publication types

  • Case Reports

MeSH terms

  • Diagnosis, Differential
  • Edetic Acid / analogs & derivatives
  • Gallium Isotopes
  • Gallium Radioisotopes
  • Humans
  • Lung Neoplasms / diagnostic imaging*
  • Lung Neoplasms / secondary
  • Male
  • Middle Aged
  • Multiple Pulmonary Nodules / diagnostic imaging*
  • Oligopeptides
  • Positron Emission Tomography Computed Tomography*
  • Prostatic Neoplasms / diagnostic imaging
  • Prostatic Neoplasms / pathology*
  • Radiopharmaceuticals

Substances

  • Gallium Isotopes
  • Gallium Radioisotopes
  • Oligopeptides
  • Radiopharmaceuticals
  • gallium 68 PSMA-11
  • Edetic Acid